BRUCEIN D, A NATURALLY OCCURRING TETRACYCLIC TRITERPENE QUASSINOID, INDUCES APOPTOSIS IN PANCREATIC CANCER THROUGH ROS-ASSOCIATED PI3K/AKT SIGNALING PATHWAY

Brucein D (BD), a major active quassinoid in Brucea javanica, has exhibited pronounced anticancer activities.However, the biologic mechanisms have not been fully explored.In this study, BD exhibited more potent cytotoxic effect on pancreatic cancer (PanCa) cell lines, while exerted weaker cytotoxic effects on GES-1 cells (non-tumorigenic).BD was sh

In the title compound, C10H11N2+·PF6−·C10H10N2, the H atom involved in protonation is disordered Fan Drive Products equally between the cation and the neutral molecule.The dihedral angle between the phenyl and imidazole rings is 82.6 (2)°.In the crystal structure, there are head-to-tail π–π stacking intera

E-scooters are gaining popularity for short-distance travel, but their recharging presents challenges.To reduce their downtime, we propose a Hybrid K-Means/Particle Swarm Optimisation (PSO) approach, optimizing charging routes using machine learning and meta-heuristics.The research in this paper attempts to determine if a combination of a meta-heur

After working on the ill-fated Niugini Mattresses Nius, Nancy Hillary moved to Alotau upon its closure in march 1990.She become one of the pioneer reporters on the Eastern Star— and survived a baptimism of fire.But it HENNA SHAMP earned her a place on The National.